The FAPI PET scan (Fibroblast Activation Protein Inhibitor Positron Emission Tomography) is an advanced imaging technique designed to detect a wide range of cancers. It targets fibroblast activation protein (FAP), which is overexpressed in many tumors, particularly in cancer-associated fibroblasts within the tumor microenvironment. The radiolabeled FAPI tracer binds to these proteins, allowing for precise imaging of tumors and metastases. FAPI PET has shown promise in detecting various cancers, including sarcomas, pancreatic cancer, and lung cancer. It provides high sensitivity for early diagnosis and is useful for treatment planning and monitoring.
1. Patient preparation: fasting, hydration
2. 68Ga-FAPI injection (typically 2-5 mCi)
3. Uptake period (30-60 minutes)
4. PET scan (10-30 minutes)
1. Cancer diagnosis and staging
2. Tumor characterization
3. Treatment response assessment
4. Cancer of unknown primary (CUP)
1. FAPI binds to Fibroblast Activation Protein (FAP) on CAFs.
2. 68Ga labels FAPI.
3. PET scanner detects positrons emitted by 68Ga.
1. FDG PET Scan: lower specificity for cancer detection
2. PSMA PET Scan: lower sensitivity for non-prostate cancer
3. MRI: lower sensitivity for small lesions
4. CT: lower sensitivity for soft tissue lesions
1. Theranostics: 177Lu-FAPI therapy
2. FAPI PET-guided biopsy
3. Artificial intelligence-based image analysis
4. Combination with other tracers (e.g., PSMA, DOTATATE)
It can detect a range of cancers, including pancreatic, sarcomas, and lung cancer.
The scan typically takes 30-60 minutes, plus time for tracer administration.
Yes, it’s a safe procedure with minimal radiation exposure and rare side effects.
Generally, no special preparation is needed, but fasting may be recommended.
Contact for appointments for Scans and Therapies.
+91-9650057298
+91-9355258181
Sector 8, Faridabad, Haryana, India