Summary in a Minute
Trans-arterial Radioembolization (TARE) is a minimally invasive, image-guided procedure used to treat liver tumors, including primary liver cancer (hepatocellular carcinoma) and metastatic liver disease. During the procedure, radioactive microspheres are injected into the arteries supplying blood to the tumor, delivering targeted radiation directly to the cancer cells. This approach helps shrink tumors and control cancer growth while minimizing damage to surrounding healthy liver tissue. TARE procedure in India is often used when surgery or other treatments are not viable and offers a promising option for managing liver tumors.
Overview
TARE is a minimally invasive, image-guided procedure for treating liver tumors.
Mechanism of Action
1. Radioactive microspheres (e.g., Yttrium-90, Holmium-166) are injected into the hepatic artery.
2. Microspheres lodge in the tumor's blood vessels, delivering radiation.
3. Radiation kills cancer cells, shrinks tumors.
Indications
1. Hepatocellular carcinoma (HCC).
2. Liver metastases (e.g., colorectal, breast, lung cancer).
3. Cholangiocarcinoma.
4. Neuroendocrine tumors.
Contra-Indications
1. Severe liver dysfunction.
2. Significant portal vein thrombosis.
3. Pregnancy or breastfeeding.
4. Known allergy to radioactive materials.
Procedure
1. Angiography: Identify tumor-feeding arteries.
2. Microcatheter placement: Deliver microspheres to tumor.
3. Radioembolization: Infuse radioactive microspheres.
4. Post-procedure imaging: Verify microsphere distribution.
Benefits
1. Minimally invasive: TARE uses a catheter to deliver treatment through blood vessels, avoiding surgery or incisions.
2. Targeted radiation delivery: Radioactive microspheres are directed specifically to tumors, minimizing radiation exposure to healthy tissue.
3. Reduced side effects: Targeted approach limits radiation to tumor cells, reducing damage to surrounding healthy tissues.
4. Improved tumor control: TARE effectively shrinks tumors, improving control over primary and metastatic liver cancers.
Side Effects
1. Fatigue.
2. Nausea and vomiting.
3. Abdominal pain.
Radioactive Microspheres
1. Yttrium-90 (Y-90) SIR-Spheres.
2. Y-90 TheraSphere.
3. Holmium-166 (Ho-166) QuiremSpheres.
Clinical Trials
1. SIRFLOX trial (NCT00724560).
2. FOXFIRE trial (NCT01730).
3. MYRIAD trial (NCT03298966).
FAQs about TARE
TARE is a minimally invasive treatment that delivers targeted radiation to tumors, primarily for liver cancer, using radioactive microspheres.
A catheter is inserted into an artery, and radioactive microspheres are injected directly into the tumor’s blood supply to deliver targeted radiation.
Yes, TARE is generally safe with minimal side effects, though some patients may experience fatigue, pain, or mild nausea.
Tumor response is typically seen within 4 to 8 weeks, with significant shrinkage occurring over several months.
Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice. Please consult with a qualified healthcare professional for any medical concerns or treatment decisions.
Contact Information
Contact for appointments for Scans and Therapies.
Phone
+91-9650057298
+91-9355258181
Address
Sector 8, Faridabad, Haryana, India
